Integrated Microfluidic Card with TaqMan Probes and High-Resolution Melt Analysis To Detect Tuberculosis Drug Resistance Mutations across 10 Genes

ABSTRACT Genotypic methods for drug susceptibility testing of Mycobacterium tuberculosis are desirable to speed the diagnosis and proper therapy of tuberculosis (TB).However, the numbers of genes and polymorphisms implicated in resistance have proliferated, challenging diagnostic design.We developed a microfluidic TaqMan array card (TAC) that utili

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Value-at-risk in the presence of asset price bubbles

In this study, we respond to the criticism that the read more value-at-risk (VaR) measure fails during financial crises and is only applicable during periods without asset price bubbles.We propose a new dating mechanism that is based on the work of Phillips (2015) to date-stamp the origination and termination of the asset price bubbles.Our method r

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Prognostic Significance of Gene Signature of Tertiary Lymphoid Structures in Patients With Lung Adenocarcinoma

BackgroundLung adenocarcinoma (LUAD) is a highly mortal cancer.Tertiary lymphoid structures (TLS) are ectopic lymphoid organs with similar morphological and molecular characters to secondary lymphoid organ.The aim of this study is to investigate the prognostic effect of a gene signature associated with TLSs, including B-cell-specific genes.MethodsC

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